0733. Impact of endotoxin challenge on disseminated intravascular coagulation in obese minipigs
نویسندگان
چکیده
Introduction An early activation of coagulation and fibrinolysis occurs during sepsis and results in a marked increase of thrombin and fibrin formation, leading to the syndrome of disseminated intravascular coagulation (DIC). DIC is a strong predictor of death and multiple organ failure in patients with septic shock [1]. Obesity has been demonstrated to be a hypercoagulable [2] and hypofibrinolytic [3] state but its impact on coagulation and fibrinolysis during sepsis has never been studied.
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