0733. Impact of endotoxin challenge on disseminated intravascular coagulation in obese minipigs

نویسندگان

  • T Duburcq
  • A Tournoys
  • F Pattou
  • T Hubert
  • V Gmyr
  • L Quintane
  • R Favory
  • J Mangalaboyi
  • M Jourdain
چکیده

Introduction An early activation of coagulation and fibrinolysis occurs during sepsis and results in a marked increase of thrombin and fibrin formation, leading to the syndrome of disseminated intravascular coagulation (DIC). DIC is a strong predictor of death and multiple organ failure in patients with septic shock [1]. Obesity has been demonstrated to be a hypercoagulable [2] and hypofibrinolytic [3] state but its impact on coagulation and fibrinolysis during sepsis has never been studied.

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عنوان ژورنال:

دوره 2  شماره 

صفحات  -

تاریخ انتشار 2014